Endocrine regulation of lipid mobilization in human obesity:

unraveling the role of atrial nutiuretic peptide

Over the last decades, the prevalence of obesity has dramatically increased,
reaching epidemic proportions and which is expected to rise even more the
coming decennia. Obesity is an important risk factor for developing
cardiometabolic complications, having a substantial impact on general health
status and thus health care. Due to an imbalance between energy storage and
energy expenditure in the obese state, energy is stored in the adipose tissue.
Upon excessive weight gain, adipose tissue dysfunction develops, which is
associated with ectopic lipid accumulation and the development of metabolic
complications like insulin resistance or type 2 diabetes mellitus.

Kenneth Verboven, July 4th 2017