Adopise tissue metabolism and cardiometabolic health in obesity
Effects of pharmological and lifestyle interventions
Obesity is associated with an increased risk for metabolic impairments and chronic
diseases, including insulin resistance, type 2 diabetes and cardiovascular
diseases. Strategies to reduce body weight and obesity-related comorbidities
include dietary (as discussed in Chapter 2), pharmacological and physical activity
interventions. This thesis describes the effects of a pharmacological intervention as
well as physical exercise interventions to improve metabolic health in obese
individuals, with a focus on adipose tissue metabolism.
An increased renin-angiotensin system activity and a lower activity of the natriuretic
peptide system have been linked to the development of type 2 diabetes and
cardiovascular disease. Combination therapy with sacubitril/valsartan, a combined
angiotensin receptor blocker (ARB) and neprilysin (NEP) inhibitor, facilitates the
beneficial effects of the natriuretic peptide system, while inhibiting the detrimental
effects of the renin-angiotensin system.
Rudi Stinkens, October 5th 2017